Gene

Twnk

Species
Rattus norvegicus
Symbol
Twnk
Name
twinkle mtDNA helicase
Synonyms
  • LOC309441
  • Peo1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial chromosome. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase).
RGD Description
Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial chromosome. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12873
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTWNK10 of 10YesYes  
Mus musculusTwnk9 of 9YesYes   
Xenopus tropicalistwnk9 of 9YesYes   
Danio reriotwnk9 of 9YesYes   
Drosophila melanogastermtDNA-helicase8 of 9YesYes   
Caenorhabditis eleganstwnk-19 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
243.868M243.869M243.870M243.871M243.872M243.873M243.874M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051336.1:g.243868961A>Cvariant
SNP
  • 5 prime UTR variant
NC_051336.1:g.243868111G>Avariant
SNP
  • intron variant
NC_051336.1:g.243872675A>Cvariant
SNP
  • intron variant
NC_051336.1:g.243870834G>Tvariant
SNP
  • intron variant
NC_051336.1:g.243874165C>Tvariant
SNP
  • 3 prime UTR variant
NC_051336.1:g.243874314C>Tvariant
SNP
  • 3 prime UTR variant
NC_051336.1:g.243868943A>Cvariant
SNP
  • 5 prime UTR variant
NC_051336.1:g.243867947C>Tvariant
SNP
  • synonymous variant
Showing 1 - 8 of 8 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
243.868M243.869M243.870M243.871M243.872M243.873M243.874M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available