Gene

Plekhm1

Species
Rattus norvegicus
Symbol
Plekhm1
Name
pleckstrin homology and RUN domain containing M1
Synonyms
  • LOC303584
  • MGC94075
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including autophagosome-lysosome fusion; positive regulation of bone resorption; and positive regulation of ruffle assembly. Predicted to be located in autolysosome and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to human PLEKHM1 (pleckstrin homology and RUN domain containing M1).
RGD Description
Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including autophagosome-lysosome fusion; positive regulation of bone resorption; and positive regulation of ruffle assembly. Predicted to be located in autolysosome and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 6 and osteopetrosis. Orthologous to human PLEKHM1 (pleckstrin homology and RUN domain containing M1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; flutamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12326
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
88.315M88.320M88.325M88.330M88.335M88.340M88.345M88.350M88.355M88.360M88.365M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions