Species

Rattus norvegicus

Symbol

Ksr1

Name

kinase suppressor of ras 1

Synonyms

kinase suppressor of ras
Ksr

Biotype

protein coding gene

Automated Description

Enables mitogen-activated protein kinase kinase binding activity. Predicted to be involved in intracellular signaling cassette; regulation of MAP kinase activity; and regulation of cell population proliferation. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1).

RGD Description

Enables mitogen-activated protein kinase kinase binding activity. Predicted to be involved in intracellular signaling cassette; regulation of MAP kinase activity; and regulation of cell population proliferation. Predicted to act upstream of or within MAPK cascade and positive regulation of MAPK cascade. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR23257

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

No data available

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr10:63961759...64098076 - (136.32 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Ksr1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Ksr1 role	Ksr1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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