Gene

Dennd4c

Species
Rattus norvegicus
Symbol
Dennd4c
Name
DENN domain containing 4C
Synonyms
  • DENN domain-containing protein 4C
  • DENN/MADD domain containing 4C
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and insulin-responsive compartment. Predicted to be part of retromer complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4C (DENN domain containing 4C).
RGD Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus and protein localization to plasma membrane. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and insulin-responsive compartment. Predicted to be part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12296
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            101.28M101.29M101.30M101.31M101.32M101.33M101.34M101.35M101.36M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Dennd4c molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Dennd4c role
              Dennd4c genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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