Version: 8.0.0
Date: Tue Jan 28 2025
Blm
Rattus norvegicusRGD:1308810
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Blm

Species
Rattus norvegicus
Symbol
Blm
Name
BLM RecQ like helicase
Synonyms
  • Bloom syndrome
  • Bloom syndrome homolog
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and regulation of primary metabolic process. Predicted to act upstream of or within several processes, including T cell differentiation; positive regulation of T cell proliferation; and regulation of DNA recombination. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase).
RGD Description
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including T cell differentiation; positive regulation of T cell proliferation; and regulation of DNA recombination. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase); PARTICIPATES IN DNA replication pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13710
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            134.41M134.42M134.43M134.44M134.45M134.46M134.47M134.48M134.49M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Blm molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Blm role
              Blm genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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