Version: 8.0.0
Date: Tue Jan 28 2025
Htra2
Rattus norvegicusRGD:1308906
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Htra2

Species
Rattus norvegicus
Symbol
Htra2
Name
HtrA serine peptidase 2
Synonyms
  • high temperature requirement protein A2
  • LOC297376
Biotype
protein coding gene
Automated Description
Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Predicted to be located in several cellular components, including chromatin; cytoplasmic side of plasma membrane; and mitochondrial intermembrane space. Predicted to be part of CD40 receptor complex and serine-type endopeptidase complex. Predicted to be active in mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2).
RGD Description
Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Predicted to be located in several cellular components, including chromatin; cytoplasmic side of plasma membrane; and mitochondrial intermembrane space. Predicted to be part of CD40 receptor complex and serine-type endopeptidase complex. Predicted to be active in mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2); PARTICIPATES IN intrinsic apoptotic pathway; Parkinson's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; clofibric acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22939
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            115.5570M115.5575M115.5580M115.5585M115.5590M115.5595M115.5600M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Htra2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Htra2 role
              Htra2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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