Species

Rattus norvegicus

Symbol

Lman2

Name

lectin, mannose-binding 2

Synonyms

Vesicular integral-membrane protein 36
vesicular integral-membrane protein VIP36

Biotype

protein coding gene

Automated Description

Predicted to enable D-mannose binding activity and heat shock protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of phagocytosis; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human LMAN2 (lectin, mannose binding 2).

RGD Description

Predicted to enable D-mannose binding activity and heat shock protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of phagocytosis; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human LMAN2 (lectin, mannose binding 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR12223

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr17:9269022...9287265 + (18.24 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Lman2 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Lman2 role	Lman2 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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