Version: 8.0.0
Date: Tue Jan 28 2025
Prkdc
Rattus norvegicusRGD:1308982
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Prkdc

Species
Rattus norvegicus
Symbol
Prkdc
Name
protein kinase, DNA-activated, catalytic subunit
Synonyms
  • DNA-dependent protein kinase catalytic subunit
  • LOC360748
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; nucleic acid binding activity; and protein serine/threonine kinase activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of metabolic process; and negative regulation of response to gamma radiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of several cellular components, including nucleus; protein-DNA complex; and small-subunit processome. Predicted to be active in chromatin and nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).
RGD Description
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; nucleic acid binding activity; and protein serine/threonine kinase activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be part of several cellular components, including nucleus; protein-DNA complex; and small-subunit processome. Predicted to be active in nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11139
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            85.06M85.08M85.10M85.12M85.14M85.16M85.18M85.20M85.22M85.24M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Prkdc molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Prkdc role
              Prkdc genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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