Gene

Pnpla2

Species
Rattus norvegicus
Symbol
Pnpla2
Name
patatin-like phospholipase domain containing 2
Synonyms
  • adipose triglyceride lipase
  • calcium-independent phospholipase A2-zeta
Biotype
protein coding gene
Automated Description
Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; intracellular triglyceride homeostasis; and lipid droplet disassembly. Predicted to act upstream of with a negative effect on lipid droplet fusion. Predicted to act upstream of or within lipid droplet organization. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2).
RGD Description
Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; intracellular triglyceride homeostasis; and lipid droplet disassembly. Predicted to act upstream of with a negative effect on lipid droplet fusion. Predicted to act upstream of or within cellular lipid catabolic process and lipid droplet organization. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2); INTERACTS WITH (+)-catechin; (-)-cotinine; (S)-nicotine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12406
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
196.5530M196.5535M196.5540M196.5545M196.5550M196.5555M196.5560M196.5565M196.5570M196.5575M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions