Gene

Ttll1

Species
Rattus norvegicus
Symbol
Ttll1
Name
TTL family tubulin polyglutamylase complex subunit L1
Synonyms
  • LOC362969
  • PGs3
Biotype
protein coding gene
Automated Description
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Predicted to be located in cytoplasm; extracellular region; and motile cilium. Predicted to be active in ciliary basal body and microtubule. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1).
RGD Description
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Predicted to be located in cytoplasm; extracellular region; and motile cilium. Predicted to be active in ciliary basal body and microtubule. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12241
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
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            114.620M114.625M114.630M114.635M114.640M114.645M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ttll1 molecule type
            Interactor gene
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              Genetic Interactions

              Ttll1 role
              Ttll1 genetic perturbation
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