Species

Rattus norvegicus

Symbol

Iscu

Name

iron-sulfur cluster assembly enzyme

Synonyms

iron-sulfur cluster assembly enzyme ISCU
iron-sulfur cluster assembly enzyme ISCU, mitochondrial

Biotype

protein coding gene

Automated Description

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; protein homodimerization activity; and transition metal ion binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; negative regulation of iron ion import across plasma membrane; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in mitochondrial matrix. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme).

RGD Description

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; protein homodimerization activity; and transition metal ion binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; negative regulation of iron ion import across plasma membrane; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in mitochondrial matrix. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR10093

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr12:42852305...42858150 - (5.85 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Iscu molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Iscu role	Iscu genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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