Version: 8.1.0
Date: Fri Apr 18 2025
Lig3
Rattus norvegicusRGD:1309875
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Lig3

Species
Rattus norvegicus
Symbol
Lig3
Name
DNA ligase 3
Synonyms
  • DNA ligase (ATP) 3
  • ligase III, DNA, ATP-dependent
Biotype
protein coding gene
Automated Description
Enables DNA ligase activity. Predicted to be involved in DNA metabolic process; mitochondrion organization; and negative regulation of mitochondrial DNA replication. Predicted to act upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm and synaptonemal complex. Predicted to be part of DNA ligase III-XRCC1 complex. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3).
RGD Description
Enables DNA ligase activity. Predicted to be involved in DNA metabolic process; mitochondrion organization; and negative regulation of mitochondrial DNA replication. Predicted to act upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm and synaptonemal complex. Predicted to be part of DNA ligase III-XRCC1 complex. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45674
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Lig3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Lig3 role
            Lig3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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