Species

Rattus norvegicus

Symbol

Pip5k1c

Name

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

Synonyms

LOC314641
MGC124518

Biotype

protein coding gene

Automated Description

Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle endocytosis. Predicted to act upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Is active in presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma).

RGD Description

Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle endocytosis. Predicted to act upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Is active in presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; E-cadherin signaling pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Brodifacoum.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR23086

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr7:8397406...8426030 - (28.62 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Pip5k1c molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Pip5k1c role	Pip5k1c genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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