Gene

Jchain

Species
Rattus norvegicus
Symbol
Jchain
Name
joining chain of multimeric IgA and IgM
Synonyms
  • Igj
  • immunoglobulin J chain
Biotype
protein coding gene
Automated Description
Predicted to enable IgA binding activity; protein homodimerization activity; and protein-macromolecule adaptor activity. Predicted to contribute to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Predicted to be involved in several processes, including glomerular filtration; innate immune response; and positive regulation of respiratory burst. Predicted to be located in extracellular space. Predicted to be part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. Orthologous to human JCHAIN (joining chain of multimeric IgA and IgM).
RGD Description
Predicted to enable IgA binding activity; protein homodimerization activity; and protein-macromolecule adaptor activity. Predicted to contribute to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Predicted to be involved in several processes, including glomerular filtration; innate immune response; and positive regulation of respiratory burst. Predicted to be located in extracellular space. Predicted to be part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. Orthologous to human JCHAIN (joining chain of multimeric IgA and IgM); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10070
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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19.539M19.540M19.541M19.542M19.543M19.544M19.545M19.546M19.547M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions