Species

Rattus norvegicus

Symbol

Tfap2a

Name

transcription factor AP-2 alpha

Synonyms

activating enhancer-binding protein 2 alpha
activating enhancer-binding protein 2-alpha

Biotype

protein coding gene

Automated Description

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator activity. Involved in Schwann cell development; positive regulation of transcription by RNA polymerase II; and response to lipopolysaccharide. Predicted to be located in clathrin-coated pit and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha).

RGD Description

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator activity. Involved in Schwann cell development; positive regulation of transcription by RNA polymerase II; and response to lipopolysaccharide. Predicted to be located in clathrin-coated pit and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR10812

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

Phenotype Term	Annotation details	References
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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr17:24024432...24047507 + (23.08 kb)

Assembly version

mRatBN7.2

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Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Tfap2a molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Tfap2a role	Tfap2a genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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