Version: 8.0.0
Date: Tue Jan 28 2025
Hnrnpa2b1
Rattus norvegicusRGD:1310403
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hnrnpa2b1

Species
Rattus norvegicus
Symbol
Hnrnpa2b1
Name
heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms
  • heterogeneous nuclear ribonucleoprotein A2
  • heterogeneous nuclear ribonucleoprotein B0a
Biotype
protein coding gene
Automated Description
Enables DNA polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and positive regulation of telomere maintenance via telomere lengthening. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1).
RGD Description
Enables DNA polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and positive regulation of telomere maintenance via telomere lengthening. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48026
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hnrnpa2b1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Hnrnpa2b1 role
            Hnrnpa2b1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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