Version: 8.0.0
Date: Tue Jan 28 2025
Nkx2-8
Rattus norvegicusRGD:1310629
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nkx2-8

Species
Rattus norvegicus
Symbol
Nkx2-8
Name
NK2 homeobox 8
Synonyms
  • homeobox protein Nkx-2.8
  • LOC299061
Biotype
protein coding gene
Automated Description
Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX2-8 (NK2 homeobox 8).
RGD Description
Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX2-8 (NK2 homeobox 8); INTERACTS WITH bisphenol A; Cuprizon; 17beta-estradiol (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nkx2-8 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Nkx2-8 role
            Nkx2-8 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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