Version: 8.0.0
Date: Tue Jan 28 2025
U2af2
Rattus norvegicusRGD:1310690
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

U2af2

Species
Rattus norvegicus
Symbol
U2af2
Name
U2 small nuclear RNA auxiliary factor 2
Synonyms
  • LOC308335
  • splicing factor U2AF 65 kDa subunit
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including C2H2 zinc finger domain binding activity; RNA binding activity; and enzyme binding activity. Predicted to be involved in negative regulation of protein ubiquitination; regulation of RNA splicing; and spliceosomal complex assembly. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type spliceosomal complex; and U2AF complex. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2).
RGD Description
Predicted to enable several functions, including C2H2 zinc finger domain binding activity; RNA binding activity; and enzyme binding activity. Predicted to be involved in negative regulation of protein ubiquitination; regulation of RNA splicing; and spliceosomal complex assembly. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type spliceosomal complex; and U2AF complex. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in developmental delay, dysmorphic facies, and brain anomalies. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23139
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          U2af2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            U2af2 role
            U2af2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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