Version: 8.0.0
Date: Tue Jan 28 2025
Pwp1
Rattus norvegicusRGD:1310705
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pwp1

Species
Rattus norvegicus
Symbol
Pwp1
Name
PWP1 homolog, endonuclein
Synonyms
  • LOC362856
  • periodic tryptophan protein 1 homolog
Biotype
protein coding gene
Automated Description
Predicted to enable H4K20me3 modified histone binding activity and histone chaperone activity. Predicted to be involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within negative regulation of peptidyl-serine phosphorylation of STAT protein and positive regulation of stem cell differentiation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleus. Orthologous to human PWP1 (PWP1 homolog, endonuclein).
RGD Description
Predicted to enable H4K20me3 modified histone binding activity and histone chaperone activity. Predicted to be involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within negative regulation of peptidyl-serine phosphorylation of STAT protein and positive regulation of stem cell differentiation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleus. Orthologous to human PWP1 (PWP1 homolog, endonuclein); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14091
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pwp1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pwp1 role
            Pwp1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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