Gene

Cradd

Species
Rattus norvegicus
Symbol
Cradd
Name
CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms
  • death domain-containing protein CRADD
  • LOC314756
Biotype
protein coding gene
Automated Description
Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cellular response to mechanical stimulus; and positive regulation of cysteine-type endopeptidase activity. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain).
RGD Description
Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of cysteine-type endopeptidase activity involved in apoptotic process; and cellular response to mechanical stimulus. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15034
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cradd molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Cradd role
            Cradd genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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