Version: 8.0.0
Date: Tue Jan 28 2025
Nek7
Rattus norvegicusRGD:1311160
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nek7

Species
Rattus norvegicus
Symbol
Nek7
Name
NIMA-related kinase 7
Synonyms
  • LOC360850
  • never in mitosis A-related kinase 7
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to potassium ion; positive regulation of cellular component organization; and protein phosphorylation. Predicted to act upstream of or within positive regulation of telomere maintenance. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in microtubule organizing center and nucleus. Orthologous to human NEK7 (NIMA related kinase 7).
RGD Description
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to potassium ion; positive regulation of cellular component organization; and protein phosphorylation. Predicted to act upstream of or within positive regulation of telomere maintenance. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in microtubule organizing center and nucleus. Orthologous to human NEK7 (NIMA related kinase 7); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; aflatoxin B1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43289
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNEK710 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusNek79 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisnek74 of 9YesYes☑ ☐☐☑☑☐☐☑☐  
Danio rerionek79 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansnekl-39 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Nek6134078716 of 9☑☐☑☐☑☑☐☑☑ 
Nek3229053373 of 9☑☐☐☐☑☐☐☑☐ 
Nek8328854363 of 9☑☐☐☐☑☐☐☑☐ 
Nek2430347333 of 9☑☐☐☐☑☐☐☑☐ 
Nek5529149333 of 9☑☐☐☐☑☐☐☑☐ 
Nek1630050342 of 9☐☐☐☐☑☐☐☑☐ 
Nek9729450352 of 9☑☐☐☐☐☐☐☑☐ 
Nek11831849282 of 9☑☐☐☐☐☐☐☑☐ 
Nek10929950322 of 9☑☐☐☐☐☐☐☑☐ 
Nek2l11030347332 of 9☐☐☐☐☑☐☐☑☐ 
Pbk1134737222 of 9☐☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051348.1:g.50023019C>Avariant
    SNP
    • 3 prime UTR variant
    NC_051348.1:g.50023448A>Gvariant
    SNP
    • 3 prime UTR variant
    NC_051348.1:g.50024643C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_051348.1:g.50026671A>Cvariant
    SNP
    • intron variant
    NC_051348.1:g.50042422T>Cvariant
    SNP
    • intron variant
    NC_051348.1:g.50067318C>Avariant
    SNP
    • intron variant
    NC_051348.1:g.50092852T>Cvariant
    SNP
    • intron variant
    NC_051348.1:g.50093940G>Avariant
    SNP
    • intron variant
    NC_051348.1:g.50126911C>Tvariant
    SNP
    • intron variant
    NC_051348.1:g.50126933A>Gvariant
    SNP
    • intron variant
    Showing 1 - 10 of 585 rows
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    View detailed Alleles/Variants information
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    1 interactor gene based on 1 annotation
    Nek7 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Mapk11Mus musculus
    protein
    • proximity labelling technology
    		PMID:31505169
    Showing 1 - 1 of 1 rows
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    Genetic Interactions

    No data available