Version: 8.0.0
Date: Tue Jan 28 2025
Phpt1
Rattus norvegicusRGD:1311355
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Phpt1

Species
Rattus norvegicus
Symbol
Phpt1
Name
phosphohistidine phosphatase 1
Synonyms
  • 14 kDa phosphohistidine phosphatase
  • LOC296571
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of ATP citrate synthase activity; negative regulation of T cell receptor signaling pathway; and peptidyl-histidine dephosphorylation. Predicted to be located in several cellular components, including cytosol; leading edge of lamellipodium; and nuclear body. Orthologous to human PHPT1 (phosphohistidine phosphatase 1).
RGD Description
Predicted to enable several functions, including calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of ATP citrate synthase activity; negative regulation of T cell receptor signaling pathway; and peptidyl-histidine dephosphorylation. Predicted to be located in leading edge of lamellipodium; nuclear body; and plasma membrane. Predicted to be active in cytosol. Orthologous to human PHPT1 (phosphohistidine phosphatase 1); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; amitrole.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12258
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Phpt1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Phpt1 role
            Phpt1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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