Gene

Setd1a

Species
Rattus norvegicus
Symbol
Setd1a
Name
SET domain containing 1A, histone lysine methyltransferase
Synonyms
  • histone-lysine N-methyltransferase SETD1A
  • LOC309001
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; beta-catenin binding activity; and histone H3K4 methyltransferase activity. Predicted to be involved in several processes, including regulation of chromatin organization; regulation of erythrocyte differentiation; and regulation of hematopoietic stem cell differentiation. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; and stem cell population maintenance. Predicted to be located in cytoplasm; euchromatin; and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Human ortholog(s) of this gene implicated in early-onset epilepsy 2 and neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase).
RGD Description
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; beta-catenin binding activity; and histone H3K4 methyltransferase activity. Predicted to be involved in several processes, including regulation of chromatin organization; regulation of erythrocyte differentiation; and regulation of hematopoietic stem cell differentiation. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; and stem cell population maintenance. Predicted to be located in cytoplasm; euchromatin; and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Human ortholog(s) of this gene implicated in early-onset epilepsy 2 and neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; INTERACTS WITH fenvalerate; 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45814
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
182.390M182.395M182.400M182.405M182.410M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions