Species

Rattus norvegicus

Symbol

Hspa9

Name

heat shock protein family A (Hsp70) member 9

Synonyms

75 kDa glucose-regulated protein
catecholamine regulated protein 40

Biotype

protein coding gene

Automated Description

Enables fibroblast growth factor binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including calcium import into the mitochondrion; cellular response to interleukin-1; and response to thyroxine. Located in mitochondrial matrix. Biomarker of Parkinsonism and brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9).

RGD Description

Enables fibroblast growth factor binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including calcium import into the mitochondrion; cellular response to interleukin-1; and response to thyroxine. Located in mitochondrial matrix. Biomarker of Parkinsonism and brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; presequence pathway of mitochondrial protein import; RNA degradation pathway; INTERACTS WITH (+)-schisandrin B; (-)-anisomycin; (R)-adrenaline.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR19375

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr18:26535798...26554294 - (18.50 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Hspa9 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Hspa9 role	Hspa9 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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