Gene

Akr1c2

Species
Rattus norvegicus
Symbol
Akr1c2
Name
aldo-keto reductase family 1, member C2
Synonyms
  • 17-alpha-HSD
  • 17-alpha-hydroxysteroid dehydrogenase
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; glycoside metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2) and AKR1C4 (aldo-keto reductase family 1 member C4).
RGD Description
Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; doxorubicin metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2) and AKR1C4 (aldo-keto reductase family 1 member C4); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11732
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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65.760M65.765M65.770M65.775M65.780M65.785M65.790M65.795M65.800M65.805M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions