Gene

Mgrn1

Species
Rattus norvegicus
Symbol
Mgrn1
Name
mahogunin ring finger 1
Synonyms
  • E3 ubiquitin-protein ligase MGRN1
  • LOC302938
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Predicted to act upstream of or within several processes, including heart development; protein polyubiquitination; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in early endosome and nucleus. Orthologous to human MGRN1 (mahogunin ring finger 1).
RGD Description
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endosome to lysosome transport; negative regulation of signal transduction; and protein monoubiquitination. Predicted to act upstream of or within several processes, including heart development; protein polyubiquitination; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in early endosome and nucleus. Orthologous to human MGRN1 (mahogunin ring finger 1); PARTICIPATES IN melanocortin system pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22996
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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10.640M10.645M10.650M10.655M10.660M10.665M10.670M10.675M10.680M10.685M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions