Gene

Mus81

Species
Rattus norvegicus
Symbol
Mus81
Name
MUS81 structure-specific endonuclease subunit
Synonyms
  • crossover junction endonuclease MUS81
  • LOC293678
Biotype
protein coding gene
Automated Description
Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nucleolus. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit).
RGD Description
Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nucleolus. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13451
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
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            202.791M202.792M202.793M202.794M202.795M202.796M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Mus81 molecule type
            Interactor gene
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              Genetic Interactions

              Mus81 role
              Mus81 genetic perturbation
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