Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.