Gene

Irf8

Species
Rattus norvegicus
Symbol
Irf8
Name
interferon regulatory factor 8
Synonyms
  • ICSBP
  • Icsbp1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11949
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
48.792M48.794M48.796M48.798M48.800M48.802M48.804M48.806M48.808M48.810M48.812M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions