Gene

Psenen

Species
Rattus norvegicus
Symbol
Psenen
Name
presenilin enhancer gamma secretase subunit
Synonyms
  • gamma-secretase subunit PEN-2
  • liver regeneration-related protein LRRGT00140
Biotype
protein coding gene
Automated Description
Predicted to enable endopeptidase activator activity and enzyme binding activity. Predicted to be involved in several processes, including amyloid-beta formation; positive regulation of endopeptidase activity; and proteolysis. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).
RGD Description
Predicted to enable endopeptidase activator activity and enzyme binding activity. Predicted to be involved in several processes, including amyloid-beta formation; membrane protein proteolysis; and positive regulation of endopeptidase activity. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-schisandrin B; acetamide; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16318
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
85.8150M85.8152M85.8154M85.8156M85.8158M85.8160M85.8162M85.8164M85.8166M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions