Version: 8.0.0
Date: Tue Jan 28 2025
Pou5f1
Rattus norvegicusRGD:1359491
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pou5f1

Species
Rattus norvegicus
Symbol
Pou5f1
Name
POU class 5 homeobox 1
Synonyms
  • POU domain, class 5, transcription factor 1
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein domain specific binding activity; and sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to benzoic acid; and response to retinoic acid. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Orthologous to human POU5F1 (POU class 5 homeobox 1) and POU5F1B (POU class 5 homeobox 1B).
RGD Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein domain specific binding activity; and sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to benzoic acid; and response to retinoic acid. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Orthologous to human POU5F1 (POU class 5 homeobox 1) and POU5F1B (POU class 5 homeobox 1B); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; all-trans-retinoic acid; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11636
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pou5f1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pou5f1 role
            Pou5f1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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