Gene

Skp1

Species
Rattus norvegicus
Symbol
Skp1
Name
S-phase kinase-associated protein 1
Synonyms
  • cyclin A/CDK2-associated p19
  • cyclin A/CDK2-associated protein p19
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; maintenance of protein location in nucleus; and positive regulation of ubiquitin protein ligase activity. Predicted to act upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in gap junction. Orthologous to human SKP1 (S-phase kinase associated protein 1).
RGD Description
Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; maintenance of protein location in nucleus; and positive regulation of ubiquitin protein ligase activity. Predicted to act upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in gap junction. Orthologous to human SKP1 (S-phase kinase associated protein 1); PARTICIPATES IN Notch signaling pathway; nuclear factor kappa B signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; Brodifacoum.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11165
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
36.402M36.404M36.406M36.408M36.410M36.412M36.414M36.416M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions