Gene

Gmppa

Species
Rattus norvegicus
Symbol
Gmppa
Name
GDP-mannose pyrophosphorylase A
Synonyms
  • GTP-mannose-1-phosphate guanylyltransferase alpha
  • mannose-1-phosphate guanyltransferase alpha
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to be involved in negative regulation of metabolic process. Predicted to act upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A).
RGD Description
Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to be involved in several processes, including negative regulation of nucleobase-containing compound metabolic process; negative regulation of phosphorus metabolic process; and negative regulation of small molecule metabolic process. Predicted to act upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A); PARTICIPATES IN amino sugar metabolic pathway; fructose and mannose metabolic pathway; nucleotide sugar metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22572
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
76.927M76.928M76.929M76.930M76.931M76.932M76.933M76.934M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions