Gene

Edar

Species
Rattus norvegicus
Symbol
Edar
Name
ectodysplasin-A receptor
Synonyms
  • LOC365581
  • RGD1561714
Biotype
protein coding gene
Automated Description
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of JNK cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle development; positive regulation of non-canonical NF-kappaB signal transduction; and salivary gland cavitation. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor).
RGD Description
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of JNK cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle development; positive regulation of non-canonical NF-kappaB signal transduction; and salivary gland cavitation. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12120
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
26.59M26.60M26.61M26.62M26.63M26.64M26.65M26.66M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions