Gene

En2

Species
Rattus norvegicus
Symbol
En2
Name
engrailed homeobox 2
Synonyms
  • engrailed 2
  • homeobox protein engrailed-2
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).
RGD Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; DDT.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24341
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
7.222M7.223M7.224M7.225M7.226M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions