Version: 8.0.0
Date: Tue Jan 28 2025
Ctnna3
Rattus norvegicusRGD:1562230
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ctnna3

Species
Rattus norvegicus
Symbol
Ctnna3
Name
catenin alpha 3
Synonyms
  • AABR07044900.1
  • catenin (cadherin associated protein), alpha 3
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity and beta-catenin binding activity. Predicted to be involved in cell migration and regulation of heart contraction. Predicted to be located in lamellipodium. Predicted to be active in adherens junction and fascia adherens. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3).
RGD Description
Predicted to enable beta-catenin binding activity. Predicted to be involved in bundle of His cell-Purkinje myocyte adhesion involved in cell communication; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell action potential. Predicted to be located in adherens junction; fascia adherens; and lamellipodium. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; endometrial cancer pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18914
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            23.8M24.0M24.2M24.4M24.6M24.8M25.0M25.2M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ctnna3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Ctnna3 role
              Ctnna3 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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