Gene

Eda

Species
Rattus norvegicus
Symbol
Eda
Name
ectodysplasin-A
Synonyms
  • LOC302424
  • RGD1563178
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Predicted to be involved in animal organ development; cytokine-mediated signaling pathway; and regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and lipid droplet. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A).
RGD Description
Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Predicted to be involved in animal organ development; cytokine-mediated signaling pathway; and regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and lipid droplet. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15151
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            65.10M65.15M65.20M65.25M65.30M65.35M65.40M65.45M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Eda molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Eda role
              Eda genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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