Version: 8.0.0
Date: Tue Jan 28 2025
Becn2
Rattus norvegicusRGD:1563293
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Becn2

Species
Rattus norvegicus
Symbol
Becn2
Name
beclin 2
Synonyms
  • beclin-2
  • LOC289269
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in cellular response to nitrogen starvation; late endosome to vacuole transport; and macroautophagy. Predicted to act upstream of or within several processes, including G protein-coupled receptor catabolic process; endosome to lysosome transport; and glucose homeostasis. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Orthologous to human BECN2 (beclin 2).
RGD Description
Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in cellular response to nitrogen starvation; late endosome to vacuole transport; and macroautophagy. Predicted to act upstream of or within several processes, including G protein-coupled receptor catabolic process; endosome to lysosome transport; and glucose homeostasis. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Orthologous to human BECN2 (beclin 2); INTERACTS WITH bisphenol A; ginsenoside Rg2 (ortholog).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12768
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            87.845M87.850M87.855M87.860M87.865M87.870M87.875M87.880M87.885M87.890M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Becn2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Becn2 role
              Becn2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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