Gene

Ldlrap1

Species
Rattus norvegicus
Symbol
Ldlrap1
Name
low density lipoprotein receptor adaptor protein 1
Synonyms
  • autosomal recessive hypercholesterolemia protein homolog
  • LOC500564
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and amyloid-beta binding activity. Predicted to be involved in several processes, including low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle clearance; and receptor-mediated endocytosis. Predicted to act upstream of or within cholesterol homeostasis. Located in axon. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1).
RGD Description
Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and amyloid-beta binding activity. Predicted to be involved in several processes, including low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle clearance; and receptor-mediated endocytosis. Predicted to act upstream of or within cholesterol homeostasis. Located in axon. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11232
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
146.956M146.958M146.960M146.962M146.964M146.966M146.968M146.970M146.972M146.974M146.976M146.978M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions