Version: 8.0.0
Date: Tue Jan 28 2025
Cul4a
Rattus norvegicusRGD:1563853
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cul4a

Species
Rattus norvegicus
Symbol
Cul4a
Name
cullin 4A
Synonyms
  • cullin-4A
  • hypothetical protein LOC361181
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin ligase complex scaffold activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to UV; positive regulation of protein catabolic process; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within several processes, including negative regulation of granulocyte differentiation; regulation of cell cycle phase transition; and regulation of nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CUL4A (cullin 4A).
RGD Description
Predicted to enable ubiquitin ligase complex scaffold activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to UV; positive regulation of protein catabolic process; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within several processes, including negative regulation of granulocyte differentiation; regulation of cell cycle phase transition; and regulation of nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CUL4A (cullin 4A); PARTICIPATES IN nucleotide excision repair pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11932
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cul4a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Cul4a role
            Cul4a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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