Predicted to enable glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like).
RGD Description
Predicted to enable glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.