Gene

Gfral

Species
Rattus norvegicus
Symbol
Gfral
Name
GDNF family receptor alpha like
Synonyms
  • GDNF family receptor alpha-like
  • LOC501023
Biotype
protein coding gene
Automated Description
Predicted to enable glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like).
RGD Description
Predicted to enable glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including GDF15-GFRAL signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10269
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
76.920M76.925M76.930M76.935M76.940M76.945M76.950M76.955M76.960M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions