Gene

Aplf

Species
Rattus norvegicus
Symbol
Aplf
Name
aprataxin and PNKP like factor
Synonyms
  • aprataxin and PNK-like factor
  • LOC500247
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Predicted to be involved in several processes, including DNA repair; DNA repair-dependent chromatin remodeling; and embryo implantation. Predicted to act upstream of or within positive regulation of DNA ligation and regulation of isotype switching. Predicted to be located in nucleoplasm. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor).
RGD Description
Predicted to enable several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Predicted to be involved in several processes, including DNA repair; DNA repair-dependent chromatin remodeling; and embryo implantation. Predicted to act upstream of or within positive regulation of DNA ligation and regulation of isotype switching. Predicted to be located in nucleoplasm. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human APLF (aprataxin and PNKP like factor); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21315
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
120.075M120.080M120.085M120.090M120.095M120.100M120.105M120.110M120.115M120.120M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions