Gene

Slx4

Species
Rattus norvegicus
Symbol
Slx4
Name
SLX4 structure-specific endonuclease subunit
Synonyms
  • BTB (POZ) domain containing 12
  • Btbd12
Biotype
protein coding gene
Automated Description
Predicted to enable enzyme activator activity. Predicted to be involved in DNA metabolic process and regulation of telomere maintenance. Predicted to act upstream of or within response to intra-S DNA damage checkpoint signaling. Predicted to be located in several cellular components, including chromosome; cytosol; and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex; Holliday junction resolvase complex; and Slx1-Slx4 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group P. Orthologous to human SLX4 (SLX4 structure-specific endonuclease subunit).
RGD Description
Predicted to enable enzyme activator activity. Predicted to be involved in DNA metabolic process and regulation of telomere maintenance. Predicted to act upstream of or within response to intra-S DNA damage checkpoint signaling. Predicted to be located in several cellular components, including chromosome; cytosol; and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex; Holliday junction resolvase complex; and Slx1-Slx4 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group P. Orthologous to human SLX4 (SLX4 structure-specific endonuclease subunit); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21541
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
11.528M11.530M11.532M11.534M11.536M11.538M11.540M11.542M11.544M11.546M11.548M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions