Gene

Oxct1

Species
Rattus norvegicus
Symbol
Oxct1
Name
3-oxoacid CoA transferase 1
Synonyms
  • 3-oxoacid CoA-transferase 1
  • 3-oxoacid-CoA transferase 1
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and succinyl-CoA:3-oxo-acid CoA-transferase activity. Involved in several processes, including positive regulation of insulin secretion involved in cellular response to glucose stimulus; response to activity; and response to ethanol. Predicted to be active in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1).
RGD Description
Enables identical protein binding activity and succinyl-CoA:3-oxo-acid CoA-transferase activity. Involved in several processes, including cellular ketone body metabolic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to activity. Predicted to be active in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13707
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
53.24M53.26M53.28M53.30M53.32M53.34M53.36M53.38M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions