Version: 8.1.0
Date: Fri Apr 18 2025
Cgas
Rattus norvegicusRGD:1586939
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cgas

Species
Rattus norvegicus
Symbol
Cgas
Name
cyclic GMP-AMP synthase
Synonyms
  • LOC682147
  • Mab-21 domain containing 1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; intracellular signal transduction; and regulation of defense response. Predicted to act upstream of or within several processes, including determination of adult lifespan; regulation of T cell activation; and regulation of gene expression. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human CGAS (cyclic GMP-AMP synthase).
RGD Description
Predicted to enable several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; intracellular signal transduction; and regulation of defense response. Predicted to act upstream of or within several processes, including determination of adult lifespan; regulation of T cell activation; and regulation of gene expression. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human CGAS (cyclic GMP-AMP synthase); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10656
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cgas molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
          Reference
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            Genetic Interactions

            Cgas role
            Cgas genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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