similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20)
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; deubiquitinase activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within several processes, including negative regulation of interleukin-1 beta production; positive regulation of protein catabolic process; and protein K63-linked deubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3).
RGD Description
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; deubiquitinase activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within several processes, including establishment of protein localization to vacuole; negative regulation of interleukin-1 beta production; and protein K63-linked deubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.