Gene

Abl2

Species
Rattus norvegicus
Symbol
Abl2
Name
ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms
  • Abelson murine leukemia viral (v-abl) oncogene homolog 2
  • Abelson murine leukemia viral (v-abl) oncogene homolog 2 (Abelson-related gene)
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of establishment of T cell polarity; and synapse maturation. Predicted to act upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase).
RGD Description
Predicted to enable metal ion binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of establishment of T cell polarity; and synapse maturation. Predicted to act upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Predicted to be located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; myocarditis pathway; INTERACTS WITH bisphenol A; C60 fullerene; dopamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
68.68M68.70M68.72M68.74M68.76M68.78M68.80M68.82M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions