jumonji and AT-rich interaction domain containing 2
Synonyms
jumonji, AT rich interactive domain 2
LOC681740
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including chromatin binding activity; ubiquitin binding activity; and ubiquitin-modified histone reader activity. Predicted to contribute to histone H3K27 methyltransferase activity. Involved in negative regulation of cardiac muscle cell proliferation and negative regulation of cardiac muscle hypertrophy. Predicted to be located in chromatin; mitochondrion; and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2).
RGD Description
Predicted to enable several functions, including chromatin binding activity; ubiquitin binding activity; and ubiquitin-modified histone reader activity. Predicted to contribute to histone H3K27 methyltransferase activity. Involved in negative regulation of cardiac muscle cell proliferation and negative regulation of cardiac muscle hypertrophy. Predicted to be located in chromatin; mitochondrion; and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.