Gene

Ncf4

Species
Rattus norvegicus
Symbol
Ncf4
Name
neutrophil cytosolic factor 4
Synonyms
  • LOC366956
  • LOC500904
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to be located in cytosol and endosome membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4).
RGD Description
Predicted to enable phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to be located in cytosol and endosome membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15706
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
109.826M109.828M109.830M109.832M109.834M109.836M109.838M109.840M109.842M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions