Version: 8.0.0
Date: Tue Jan 28 2025
Atm
Rattus norvegicusRGD:1593265
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Atm

Species
Rattus norvegicus
Symbol
Atm
Name
ATM serine/threonine kinase
Synonyms
  • Ataxia telangiectasia gene mutated in human beings
  • ataxia telangiectasia mutated
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including cellular response to ionizing radiation; positive regulation of DNA catabolic process; and regulation of microglial cell activation. Predicted to be located in chromosome, telomeric region; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of DNA repair complex. Predicted to be active in nucleus; peroxisomal matrix; and site of double-strand break. Predicted to be extrinsic component of synaptic vesicle membrane. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase).
RGD Description
Predicted to enable identical protein binding activity and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including cellular response to ionizing radiation; positive regulation of DNA catabolic process; and regulation of microglial cell activation. Predicted to be located in chromosome, telomeric region; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of DNA repair complex. Predicted to be active in nucleus; peroxisomal matrix; and site of double-strand break. Predicted to be extrinsic component of synaptic vesicle membrane. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; nuclear factor kappa B signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR37079
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Atm molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Atm role
            Atm genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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