Version: 8.0.0
Date: Tue Jan 28 2025
Nlrp1b
Rattus norvegicusRGD:1593294
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nlrp1b

Species
Rattus norvegicus
Symbol
Nlrp1b
Name
NLR family, pyrin domain containing 1B
Synonyms
  • AABR07029890.1
  • LOC691998
Biotype
protein coding gene
Automated Description
Predicted to enable cysteine-type endopeptidase activator activity and pattern recognition receptor activity. Predicted to be involved in activation of innate immune response; inflammatory response; and intrinsic apoptotic signaling pathway. Predicted to be located in neuronal cell body. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inflammatory bowel disease 30 and vitiligo. Orthologous to several human genes including NLRP1 (NLR family pyrin domain containing 1).
RGD Description
Predicted to enable ATP binding activity; peptidase activity; and scaffold protein binding activity. Predicted to be involved in several processes, including inflammatory response; innate immune response; and regulation of defense response. Predicted to be located in neuronal cell body. Predicted to be part of canonical inflammasome complex. Human ortholog(s) of this gene implicated in inflammatory bowel disease 30 and vitiligo. Orthologous to several human genes including NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN NOD-like receptor signaling pathway; .
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46985
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nlrp1b molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Nlrp1b role
            Nlrp1b genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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